Topic: Hexane
no photo
Sun 11/27/11 09:26 AM
Why is hexane considered carcinogenic? The stock bottle has that label. What's the biological degradation pathway?

smokeybette's photo
Sun 11/27/11 09:34 AM

google it, duh.
why do peeps ask questions on here
when their computer will find the answers?

Conrad_73's photo
Sun 11/27/11 09:34 AM

Why is hexane considered carcinogenic? The stock bottle has that label. What's the biological degradation pathway?
Wiki has an Article on it,and also contains some External links!
A search on Google brings up more!

http://en.wikipedia.org/wiki/Hexane

http://www.google.ch/search?q=hexane&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a

s1owhand's photo
Sun 11/27/11 09:39 AM
http://www.epa.gov/ttn/atw/hlthef/hexane.html

seems to be only as a possible carcinogen - above article states
that no evidence has been found in humans or other animals

"In 2001, the U.S. Environmental Protection Agency issued regulations on the control of emissions of hexane gas due to its potential carcinogenic properties and environmental concerns.[9]"

from the Wiki

motowndowntown's photo
Sun 11/27/11 11:06 AM
And why are we interested in something as nasty as hexane?

Are we building a rocket engine?

no photo
Sun 11/27/11 11:50 AM


google it, duh.
why do peeps ask questions on here
when their computer will find the answers?


Its called "conversation", and conversation motivated by a question like this is far, far more interesting to me than a conversation motivated by the question "Would you spank the person above you?"


NoParadox, thanks for asking your question. You got a 'friend' who inhales hexane for the slight pleasure it brings?

Conrad_73's photo
Sun 11/27/11 01:03 PM

And why are we interested in something as nasty as hexane?

Are we building a rocket engine?
laugh Diesel or Kerosene work,and would be less conspicuous!bigsmile

no photo
Mon 11/28/11 08:57 AM
Edited by Bushidobillyclub on Mon 11/28/11 09:22 AM



google it, duh.
why do peeps ask questions on here
when their computer will find the answers?


Its called "conversation", and conversation motivated by a question like this is far, far more interesting to me than a conversation motivated by the question "Would you spank the person above you?"


NoParadox, thanks for asking your question. You got a 'friend' who inhales hexane for the slight pleasure it brings?
I agree. I had never heard of it, and this prompted me to learn something. That to me is enjoyable and all together what a science forum should be all about!

Uses

In industry, hexanes are used in the formulation of glues for shoes, leather products, and roofing. They are also used to extract cooking oils from seeds, for cleansing and degreasing all sorts of items, and in textile manufacturing.

A typical laboratory use of hexanes is to extract oil and grease contaminants from water and soil for analysis.[3] Since hexane cannot be easily deprotonated, it is used in the laboratory for reactions that involve very strong bases, such as the preparation of organolithiums, e.g. Butyllithiums are typically supplied as a hexane solution.

In many applications (especially pharmaceutical), the use of n-hexane is being phased out due to its long term toxicity, and often replaced by n-heptane, which will not form the toxic (hexane-2,5-dione) metabolite.
[edit] Production

Hexanes are chiefly obtained by the refining of crude oil. The exact composition of the fraction depends largely on the source of the oil (crude or reformed) and the constraints of the refining. The industrial product (usually around 50% by weight of the straight-chain isomer) is the fraction boiling at 65–70 °C.


I would say that based on the fact it is a hydrocarbon, and most hydrocarbons that have had long term testing have shown carcinogenic properties would be the main reason it has a warning.


no photo
Wed 11/30/11 06:19 PM
Ah yes, Massagetrade was correct, it was more for sake of conversation. I work with the stuff on a daily basis, among many other things, and not having read many details about it, it was interesting to see people's answers. I'm not very biologically-oriented, so it's also interesting to see how an alkane could exhibit reactivity in the body.

no photo
Wed 11/30/11 06:21 PM
Aromatics, usually those which don't contain hydrophilic groups such as sulphates or sulphonates tend to be carcinogenic. Alkanes are unreactive under normal conditions, other than through radical pathways.





google it, duh.
why do peeps ask questions on here
when their computer will find the answers?


Its called "conversation", and conversation motivated by a question like this is far, far more interesting to me than a conversation motivated by the question "Would you spank the person above you?"


NoParadox, thanks for asking your question. You got a 'friend' who inhales hexane for the slight pleasure it brings?
I agree. I had never heard of it, and this prompted me to learn something. That to me is enjoyable and all together what a science forum should be all about!

Uses

In industry, hexanes are used in the formulation of glues for shoes, leather products, and roofing. They are also used to extract cooking oils from seeds, for cleansing and degreasing all sorts of items, and in textile manufacturing.

A typical laboratory use of hexanes is to extract oil and grease contaminants from water and soil for analysis.[3] Since hexane cannot be easily deprotonated, it is used in the laboratory for reactions that involve very strong bases, such as the preparation of organolithiums, e.g. Butyllithiums are typically supplied as a hexane solution.

In many applications (especially pharmaceutical), the use of n-hexane is being phased out due to its long term toxicity, and often replaced by n-heptane, which will not form the toxic (hexane-2,5-dione) metabolite.
[edit] Production

Hexanes are chiefly obtained by the refining of crude oil. The exact composition of the fraction depends largely on the source of the oil (crude or reformed) and the constraints of the refining. The industrial product (usually around 50% by weight of the straight-chain isomer) is the fraction boiling at 65–70 °C.


I would say that based on the fact it is a hydrocarbon, and most hydrocarbons that have had long term testing have shown carcinogenic properties would be the main reason it has a warning.



metalwing's photo
Thu 12/01/11 02:03 PM
When dealing with hydrocarbons, the straight chains make good solvents, burn clean, thin paint well, and offer many uses that are not very harmful to humans when exposed. Hexane is in the little block of molecules that can form other variations that are, indeed, harmful.

Check out xylene. The chemical bonds to make it are sufficiently similar to make it a cousin, but xylene is super bad news for humans.

C6H4C2H6 vs C6H14

They are both just hydrocarbons, common solvents we deal with daily, and ohhhhh so different when absorbed into the skin.

Care should be used with toluene, benzene, methyl benzene, etc.

I used quite a bit of it before the headaches made me wise up.happy I try to use methylethylketone when possible.

Conrad_73's photo
Thu 12/01/11 02:17 PM

When dealing with hydrocarbons, the straight chains make good solvents, burn clean, thin paint well, and offer many uses that are not very harmful to humans when exposed. Hexane is in the little block of molecules that can form other variations that are, indeed, harmful.

Check out xylene. The chemical bonds to make it are sufficiently similar to make it a cousin, but xylene is super bad news for humans.

C6H4C2H6 vs C6H14

They are both just hydrocarbons, common solvents we deal with daily, and ohhhhh so different when absorbed into the skin.

Care should be used with toluene, benzene, methyl benzene, etc.

I used quite a bit of it before the headaches made me wise up.happy I try to use methylethylketone when possible.
all of them just as dangerous!
Better not order a 55gal Drum to your Homeaddress,or Eyebrows will go up at the DEA and the BATF!laugh

metalwing's photo
Thu 12/01/11 02:21 PM


When dealing with hydrocarbons, the straight chains make good solvents, burn clean, thin paint well, and offer many uses that are not very harmful to humans when exposed. Hexane is in the little block of molecules that can form other variations that are, indeed, harmful.

Check out xylene. The chemical bonds to make it are sufficiently similar to make it a cousin, but xylene is super bad news for humans.

C6H4C2H6 vs C6H14

They are both just hydrocarbons, common solvents we deal with daily, and ohhhhh so different when absorbed into the skin.

Care should be used with toluene, benzene, methyl benzene, etc.

I used quite a bit of it before the headaches made me wise up.happy I try to use methylethylketone when possible.
all of them just as dangerous!
Better not order a 55gal Drum to your Homeaddress,or Eyebrows will go up at the DEA and the BATF!laugh


I probably have about twenty gallons, a gallon or two of each. Some are pretty scary and some just make good paint thinner. Some cut epoxy, some remove paint, some stink a lot and don't seem to do much but are required to thin complex polymers. They all have different properties.

no photo
Fri 12/02/11 09:36 PM
Suprisingly, methylbenzene (toluene, isn't as bad as the simple or halogenated aromatics. I still find it counter-intuitive for alkanes to be toxic, as they don't have functional groups to be metabolized in the body.

no photo
Fri 12/02/11 11:12 PM

Why is hexane considered carcinogenic?


Because it causes cancer.


The stock bottle has that label.


I told you that in confidence!


What's the biological degradation pathway?


It's through the trans-differential hemophlange, if you get to the oscillating calcifer, you've gone too far.

Conrad_73's photo
Sat 12/03/11 12:48 AM



When dealing with hydrocarbons, the straight chains make good solvents, burn clean, thin paint well, and offer many uses that are not very harmful to humans when exposed. Hexane is in the little block of molecules that can form other variations that are, indeed, harmful.

Check out xylene. The chemical bonds to make it are sufficiently similar to make it a cousin, but xylene is super bad news for humans.

C6H4C2H6 vs C6H14

They are both just hydrocarbons, common solvents we deal with daily, and ohhhhh so different when absorbed into the skin.

Care should be used with toluene, benzene, methyl benzene, etc.

I used quite a bit of it before the headaches made me wise up.happy I try to use methylethylketone when possible.
all of them just as dangerous!
Better not order a 55gal Drum to your Homeaddress,or Eyebrows will go up at the DEA and the BATF!laugh


I probably have about twenty gallons, a gallon or two of each. Some are pretty scary and some just make good paint thinner. Some cut epoxy, some remove paint, some stink a lot and don't seem to do much but are required to thin complex polymers. They all have different properties.
allso make some pretty nasty Peroxides and tri-Nitrates.bigsmile