Topic: Anyone on here have Gilbert Syndrome? | |
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If so can you please discuss what it does to you and what you eat with it, so you don't get pain from it. Doctors say it don't effect you, but it really does.
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Does it make you squint your eyes and talk in a loud shrill voice? |
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No.
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Never heard of it. |
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What It Is
The body has a two-phase detoxification system. Depending on the toxin, the first phase can either detoxify it entirely or prepare it for the second phase. In the second phase there are several major systems which act on these toxins. The one affected by Gilbert's Syndrome is the glucuronidation system, which "conjugates" the toxins so they can be removed from the body. Enzymes in the glucuronidation system are called uridine diphosphate glucuronyl transferase, or UGT for short. UGT1A1, for example, refers to a specific enzyme in this family. Gilbert's syndrome is due to a genetic mutation that causes only 30% of the enzyme UGT1A1 to be produced. This is the only enzyme that detoxifies bilirubin, a toxic product of the natural breakdown of red blood cells. This enzymatic shortage leads to an excess of bilirubin (and other toxins) in the blood serum. Most people with Gilbert's Syndrome also have linked mutations in two other enzymes - UGT1A6 and UGT1A7, causing similar enzyme shortages which leads to their related toxins circulating in the body for longer periods as well. The things acted upon by these enzymes include many carcinogens, drugs, hormones, and various other toxins. |
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hmmm never heard of it , but heard a lot about Mingle Syndrome..LOL
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There is probably a support site you can get on an they will have better answer then anyone here. Good luck!
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